Circular RNA circVAPA regulates breast cancer cell migration and invasion via sponging miR-130a-5p.
Epigenomics
; 12(4): 303-317, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31920104
ABSTRACT
Aim:
We aimed to explore the roles of circular RNA, circVAPA in regulating cell migration and invasion of breast cancer. Materials &methods:
CircVAPA expression was detected in breast cancer tissues and cells. The role of circVAPA was evaluated by MTT assay, wound-healing and transwell assay. The relationship between circVAPA and miR-130a-5p and the location of circVAPA were explored.Results:
We discovered that circVAPA was dysregulated in breast cancer tissues and cells. Ectopic circVAPA regulated breast cancer migration, invasion and proliferation. CircVAPA was mainly expressed in the cytoplasm and could act as a miRNA sponge for miR-130a-5p, but did not regulate its parental gene.Conclusion:
CircVAPA may promote migration and invasion capacity of breast cancer via harboring miR-130a-5p.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
MicroRNAs
/
RNA Circular
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article