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Cigarette smoking increases the risk of nasopharyngeal carcinoma through the elevated level of IgA antibody against Epstein-Barr virus capsid antigen: A mediation analysis.
Hsu, Wan-Lun; Chien, Yin-Chu; Huang, Yen-Tsung; Yu, Kelly J; Ko, Jenq-Yuh; Lin, Ching-Yuan; Tsou, Yung-An; Leu, Yi-Shing; Liao, Li-Jen; Chang, Yen-Liang; Su, Jia-Ying; Liu, Zhiwei; Wang, Cheng-Ping; Terng, Shyuang-Der; Hua, Chun-Hung; Lee, Jehn-Chuan; Yang, Tsung-Lin; Kate Hsiao, Chu-Hsing; Wu, Ming-Shiang; Tsai, Ming-Hsui; Liu, Ming-Jiung; Lou, Pei-Jen; Hildesheim, Allan; Chen, Chien-Jen.
Afiliação
  • Hsu WL; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Chien YC; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Huang YT; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.
  • Yu KJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
  • Ko JY; Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Lin CY; Department of Head and Neck Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
  • Tsou YA; Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.
  • Leu YS; Department of Otolaryngology, MacKay Memorial Hospital, Taipei, Taiwan.
  • Liao LJ; Department of Otolaryngology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
  • Chang YL; Department of Otolaryngology, Cathay General Hospital, Taipei, Taiwan.
  • Su JY; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.
  • Liu Z; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
  • Wang CP; Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Terng SD; Department of Head and Neck Surgery, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
  • Hua CH; Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.
  • Lee JC; Department of Otolaryngology, MacKay Memorial Hospital, Taipei, Taiwan.
  • Yang TL; Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Kate Hsiao CH; Graduate Institute of Epidemiology and Preventative Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
  • Wu MS; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
  • Tsai MH; Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.
  • Liu MJ; Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
  • Lou PJ; Department of Otolaryngology, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan.
  • Hildesheim A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
  • Chen CJ; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
Cancer Med ; 9(5): 1867-1876, 2020 03.
Article em En | MEDLINE | ID: mdl-31925935
BACKGROUND: The study aims are to evaluate the associations between nasopharyngeal carcinoma (NPC) risk and cigarette smoking and to explore the effects of cigarette smoking on Epstein-Barr virus (EBV) infection for NPC risk. METHODS: 1235 male NPC cases and 1262 hospital-based male controls matched to cases were recruited across six collaborative hospitals between 2010 and 2014. Using a standardized questionnaire, information on cigarette smoking and other potential risk factors for NPC was obtained. Blood was collected and used for anti-EBV VCA IgA and anti-EBV EA-EBNA1 IgA testing using standard methods. Unconditional logistic regression analysis was used to estimate odds ratio (OR) with 95% confidence interval (CI) for each risk factor after adjusting for confounders. RESULTS: 63.6% of cases and 44.0% of controls reported ever smoking cigarettes. After full adjustment, current smokers had a significant 1.60-fold (95% CI = 1.30-1.97) and former smokers a borderline significant 1.27-fold (95% CI = 1.00-1.60) increased NPC risk compared to never smokers. NPC risk increased with increasing duration, intensity, and pack-years of cigarette smoking but not with age at smoking initiation. Among controls, anti-EBV VCA IgA seropositivity rate was higher in current smokers than never smokers (14.0% vs 8.4%; OR = 1.82; 95% CI = 1.19-2.79). Mediation analyses showed that more than 90% of the cigarette smoking effect on NPC risk is mediated through anti-EBV VCA IgA. CONCLUSION: This study confirms the association between long-term cigarette smoking and NPC and demonstrates that current smoking is associated with seropositivity of anti-EBV VCA IgA antibodies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Herpesvirus Humano 4 / Infecções por Vírus Epstein-Barr / Fumar Cigarros / Carcinoma Nasofaríngeo Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Nasofaríngeas / Herpesvirus Humano 4 / Infecções por Vírus Epstein-Barr / Fumar Cigarros / Carcinoma Nasofaríngeo Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article