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Targeting BRD/BET proteins inhibits adaptive kinome upregulation and enhances the effects of BRAF/MEK inhibitors in melanoma.
Tiago, Manoela; Capparelli, Claudia; Erkes, Dan A; Purwin, Timothy J; Heilman, Shea A; Berger, Adam C; Davies, Michael A; Aplin, Andrew E.
Afiliação
  • Tiago M; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Capparelli C; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Erkes DA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Purwin TJ; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Heilman SA; Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Berger AC; Department of Surgery, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Davies MA; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA.
  • Aplin AE; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Br J Cancer ; 122(6): 789-800, 2020 03.
Article em En | MEDLINE | ID: mdl-31932756
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Melanoma Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas B-raf / Inibidores de Proteínas Quinases / Melanoma Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article