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Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine.
Du, Guangyan; Rao, Suman; Gurbani, Deepak; Henning, Nathaniel J; Jiang, Jie; Che, Jianwei; Yang, Annan; Ficarro, Scott B; Marto, Jarrod A; Aguirre, Andrew J; Sorger, Peter K; Westover, Kenneth D; Zhang, Tinghu; Gray, Nathanael S.
Afiliação
  • Du G; Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.
  • Rao S; Department of Cancer Biology , Dana Farber Cancer Institute , 450 Brookline Avenue , Boston , Massachusetts 02215 , United States.
  • Gurbani D; Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.
  • Henning NJ; Department of Cancer Biology , Dana Farber Cancer Institute , 450 Brookline Avenue , Boston , Massachusetts 02215 , United States.
  • Jiang J; Laboratory of Systems Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.
  • Che J; Departments of Biochemistry and Radiation Oncology , The University of Texas Southwestern Medical Center at Dallas , Dallas , Texas 75390 , United States.
  • Yang A; Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.
  • Ficarro SB; Department of Cancer Biology , Dana Farber Cancer Institute , 450 Brookline Avenue , Boston , Massachusetts 02215 , United States.
  • Marto JA; Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.
  • Aguirre AJ; Department of Cancer Biology , Dana Farber Cancer Institute , 450 Brookline Avenue , Boston , Massachusetts 02215 , United States.
  • Sorger PK; Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.
  • Westover KD; Department of Cancer Biology , Dana Farber Cancer Institute , 450 Brookline Avenue , Boston , Massachusetts 02215 , United States.
  • Zhang T; Department of Medical Oncology , Dana Farber Cancer Institute , 450 Brookline Avenue , Boston , Massachusetts 02215 , United States.
  • Gray NS; Department of Biological Chemistry and Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.
J Med Chem ; 63(4): 1624-1641, 2020 02 27.
Article em En | MEDLINE | ID: mdl-31935084
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Quinases da Família src / Cisteína / Inibidores de Proteínas Quinases / Anilidas Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Quinases da Família src / Cisteína / Inibidores de Proteínas Quinases / Anilidas Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article