Expression of Melatonin and Dopamine D<sub>3</sub> Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension.

Reyes-Resina, Irene; Awad Alkozi, Hanan; Del Ser-Badia, Anna; Sánchez-Naves, Juan; Lillo, Jaume; Jiménez, Jasmina; Pintor, Jesús; Navarro, Gemma; Franco, Rafael

Expression of Melatonin and Dopamine D₃ Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension.

Reyes-Resina, Irene; Awad Alkozi, Hanan; Del Ser-Badia, Anna; Sánchez-Naves, Juan; Lillo, Jaume; Jiménez, Jasmina; Pintor, Jesús; Navarro, Gemma; Franco, Rafael.

Afiliação

Reyes-Resina I; Department of Biochemistry and Molecular Biomedicine, School of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.
Awad Alkozi H; Neuroplasticity Research Group, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany.
Del Ser-Badia A; Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Sánchez-Naves J; Department of Biochemistry and Molecular Biology, Faculty of Optics and Optometry, University Complutense of Madrid, 28037 Madrid, Spain.
Lillo J; Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Jiménez J; Department de Bioquímica i Biologia Molecular, Institut de Neurociències, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.
Pintor J; Department of Ophthalmology, Balearic Islands Institute of Ophthalmology, 07013 Palma de Mallorca, Mallorca, Spain.
Navarro G; Department of Biochemistry and Molecular Biomedicine, School of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.
Franco R; Centro de Investigación en Red, Enfermedades Neurodegenerativas, CiberNed, Instituto de Salud Carlos III, 28029 Madrid, Spain.

Cells ; 9(1)2020 01 08.

Article em En | MEDLINE | ID: mdl-31936298

Assuntos

Corpo Ciliar/metabolismo; Células Epiteliais/metabolismo; Glaucoma/patologia; Hipertensão Ocular/patologia; Receptor MT1 de Melatonina/metabolismo; Receptor MT2 de Melatonina/metabolismo; Receptores de Dopamina D3/metabolismo; Estudos de Casos e Controles; Glaucoma/metabolismo; Células HEK293; Humanos; Hipertensão Ocular/metabolismo; Multimerização Proteica

Palavras-chave

G protein coupling; G-protein-coupled receptor GPCR heteromer; circadian rhythm; glaucoma; human 59HCE cells; label-free dynamic mass redistribution (DMR); melatonin MT1 and MT2 receptors; mitogen-activated protein kinase pathway (MAPK); retina

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glaucoma / Hipertensão Ocular / Corpo Ciliar / Receptor MT1 de Melatonina / Receptor MT2 de Melatonina / Células Epiteliais / Receptores de Dopamina D3 Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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