Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients.

Dai, Yuanyuan; Amenov, Asset; Ignatyeva, Nadezda; Koschinski, Andreas; Xu, Hang; Soong, Poh Loong; Tiburcy, Malte; Linke, Wolfgang A; Zaccolo, Manuela; Hasenfuss, Gerd; Zimmermann, Wolfram-Hubertus; Ebert, Antje

Dai, Yuanyuan; Amenov, Asset; Ignatyeva, Nadezda; Koschinski, Andreas; Xu, Hang; Soong, Poh Loong; Tiburcy, Malte; Linke, Wolfgang A; Zaccolo, Manuela; Hasenfuss, Gerd; Zimmermann, Wolfram-Hubertus; Ebert, Antje.

Afiliação

Dai Y; Heart Center, Department of Cardiology and Pneumology, Goettingen, Germany.
Amenov A; DZHK (German Center for Cardiovascular Research), partner site, Goettingen, Germany.
Ignatyeva N; Heart Center, Department of Cardiology and Pneumology, Goettingen, Germany.
Koschinski A; DZHK (German Center for Cardiovascular Research), partner site, Goettingen, Germany.
Xu H; Heart Center, Department of Cardiology and Pneumology, Goettingen, Germany.
Soong PL; DZHK (German Center for Cardiovascular Research), partner site, Goettingen, Germany.
Tiburcy M; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Linke WA; Heart Center, Department of Cardiology and Pneumology, Goettingen, Germany.
Zaccolo M; DZHK (German Center for Cardiovascular Research), partner site, Goettingen, Germany.
Hasenfuss G; Institute of Pharmacology, University of Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.
Zimmermann WH; DZHK (German Center for Cardiovascular Research), partner site, Goettingen, Germany.
Ebert A; Institute of Pharmacology, University of Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.

Sci Rep ; 10(1): 209, 2020 01 14.

Article em En | MEDLINE | ID: mdl-31937807

Assuntos

Cardiomiopatia Dilatada/patologia; Diferenciação Celular; Citoesqueleto/metabolismo; Células-Tronco Pluripotentes Induzidas/patologia; Miócitos Cardíacos/patologia; Sarcômeros/patologia; Troponina/química; Cálcio/metabolismo; Cardiomiopatia Dilatada/metabolismo; Acoplamento Excitação-Contração; Humanos; Células-Tronco Pluripotentes Induzidas/metabolismo; Mutação; Contração Miocárdica; Miócitos Cardíacos/metabolismo; Sarcômeros/metabolismo; Troponina/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sarcômeros / Troponina / Citoesqueleto / Cardiomiopatia Dilatada / Diferenciação Celular / Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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