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The role of fenhexamid on the proliferation of ovarian cancer BG-1 cells.
Fei, Anxing; Fu, Handong; Jiang, Hong; Wei, Liping; Zhang, Hongxia; Fei, Anqiong; Zhang, Yan; Zou, Tiantian; Gao, Shuzhen; Li, Lin; Jiang, Hong; Zhou, Min; Xing, Hui; Huang, Yanli.
Afiliação
  • Fei A; Laboratory Department (Clinical Laboratory) of Huangshi Maternal and Child Health Hospital Huangshi 435000, Hubei, P. R. China.
  • Fu H; Xiaogan Hospital Affiliated to Wuhan University of Science and Technology Xiaogan 432100, Hubei, P. R. China.
  • Jiang H; Laboratory Department (Clinical Laboratory) of Huangshi Maternal and Child Health Hospital Huangshi 435000, Hubei, P. R. China.
  • Wei L; Laboratory Department (Clinical Laboratory) of Huangshi Maternal and Child Health Hospital Huangshi 435000, Hubei, P. R. China.
  • Zhang H; Laboratory Department (Clinical Laboratory) of Huangshi Maternal and Child Health Hospital Huangshi 435000, Hubei, P. R. China.
  • Fei A; Daye General Hospital Huangshi 435100, Hubei, P. R. China.
  • Zhang Y; Laboratory Department (Clinical Laboratory) of Huangshi Maternal and Child Health Hospital Huangshi 435000, Hubei, P. R. China.
  • Zou T; Laboratory Department (Clinical Laboratory) of Huangshi Maternal and Child Health Hospital Huangshi 435000, Hubei, P. R. China.
  • Gao S; Laboratory Department (Clinical Laboratory) of Huangshi Maternal and Child Health Hospital Huangshi 435000, Hubei, P. R. China.
  • Li L; Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, Hubei, P. R. China.
  • Jiang H; Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, Hubei, P. R. China.
  • Zhou M; Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, Hubei, P. R. China.
  • Xing H; Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, Hubei, P. R. China.
  • Huang Y; Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science Xiangyang 441021, Hubei, P. R. China.
Int J Clin Exp Pathol ; 11(4): 2025-2031, 2018.
Article em En | MEDLINE | ID: mdl-31938309
ABSTRACT
To study the influence of fenhexamid in pesticide residue to the human ovarian cancer BG-1 cell proliferation. Detecting the effectiveness of 17ß-estradiol, fenhexamid and Fulvestrant to BG-1 cell proliferation by MTT, and detecting the expression levels of cyclin D1 and cyclin E by Western blot. Fenhexamid can promote BG-1 cell proliferation for its estrogen-like effect. On the other hand, it can help to improve the expression levels of cyclin D1 and cyclin E in BG-1 cells which is regulated by ER-dependent pathway. And 17ß-estradiol is also regulated by the same way. The existence of fenhexamid can promote ovarian cancer cell proliferation, so for patients with ovarian cancer, fenhexamid in pesticide residue may make medical conditions worse.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2018 Tipo de documento: Article