Characterization of Human Induced Pluripotent Stem Cell-Derived Hepatocytes with Mature Features and Potential for Modeling Metabolic Diseases.

Holmgren, Gustav; Ulfenborg, Benjamin; Asplund, Annika; Toet, Karin; Andersson, Christian X; Hammarstedt, Ann; Hanemaaijer, Roeland; Küppers-Munther, Barbara; Synnergren, Jane

Holmgren, Gustav; Ulfenborg, Benjamin; Asplund, Annika; Toet, Karin; Andersson, Christian X; Hammarstedt, Ann; Hanemaaijer, Roeland; Küppers-Munther, Barbara; Synnergren, Jane.

Afiliação

Holmgren G; Systems biology research center, School of Bioscience, University of Skövde, 54128 Skövde, Sweden.
Ulfenborg B; Systems biology research center, School of Bioscience, University of Skövde, 54128 Skövde, Sweden.
Asplund A; R&D, Hepatocyte Product Development, Takara Bio Europe AB, 41346 Gothenburg, Sweden.
Toet K; Department of Metabolic Health Research, TNO, 2333 Leiden, The Netherlands.
Andersson CX; R&D, Hepatocyte Product Development, Takara Bio Europe AB, 41346 Gothenburg, Sweden.
Hammarstedt A; The Lundberg Laboratory for Diabetes Research, Departments of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden.
Hanemaaijer R; Department of Metabolic Health Research, TNO, 2333 Leiden, The Netherlands.
Küppers-Munther B; R&D, Hepatocyte Product Development, Takara Bio Europe AB, 41346 Gothenburg, Sweden.
Synnergren J; Systems biology research center, School of Bioscience, University of Skövde, 54128 Skövde, Sweden.

Int J Mol Sci ; 21(2)2020 Jan 11.

Article em En | MEDLINE | ID: mdl-31940797

Assuntos

Hepatócitos/metabolismo; Células-Tronco Pluripotentes Induzidas/metabolismo; Doenças Metabólicas/metabolismo; Transcriptoma; Idoso; Diferenciação Celular; Linhagem Celular; Células Cultivadas; Estresse do Retículo Endoplasmático; Metabolismo Energético; Ácidos Graxos/metabolismo; Feminino; Glucose/metabolismo; Hepatócitos/citologia; Humanos; Células-Tronco Pluripotentes Induzidas/citologia; Lipoproteínas LDL/metabolismo; Masculino; Doenças Metabólicas/genética; Pessoa de Meia-Idade; Cultura Primária de Células/métodos; Esferoides Celulares/citologia; Esferoides Celulares/metabolismo

Palavras-chave

characterization; human induced pluripotent stem cells; human stem cell-derived hepatocytes; in vitro; maturation; metabolic diseases; transcriptomics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hepatócitos / Células-Tronco Pluripotentes Induzidas / Transcriptoma / Doenças Metabólicas Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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