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Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics.
Ponroy Bally, Blandine; Farmer, W Todd; Jones, Emma V; Jessa, Selin; Kacerovsky, J Benjamin; Mayran, Alexandre; Peng, Huashan; Lefebvre, Julie L; Drouin, Jacques; Hayer, Arnold; Ernst, Carl; Murai, Keith K.
Afiliação
  • Ponroy Bally B; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
  • Farmer WT; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
  • Jones EV; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
  • Jessa S; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
  • Kacerovsky JB; Quantitative Life Sciences, McGill University, Montreal, QC H3A 2A7, Canada.
  • Mayran A; Department of Neurology & Neurosurgery, Brain Repair and Integrative Neuroscience Program, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
  • Peng H; Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada.
  • Lefebvre JL; Department of Psychiatry, McGill University, Montreal, QC H4H 1R3, Canada.
  • Drouin J; Department of Human Genetics, McGill University, Montreal, QC H4H 1R3, Canada.
  • Hayer A; Douglas Hospital Research Institute, Verdun, QC H4H 1R3, Canada.
  • Ernst C; Department of Molecular Genetics, Program for Neuroscience and Mental Health, Hospital for Sick Children, University of Toronto, Toronto, ON M5G 0A4, Canada.
  • Murai KK; Institut de Recherches Cliniques de Montréal (IRCM), Montreal, QC H2W 1R7, Canada.
Hum Mol Genet ; 29(5): 785-802, 2020 03 27.
Article em En | MEDLINE | ID: mdl-31943018
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Adesão Celular / Regulação da Expressão Gênica / Astrócitos / Síndrome de Down / Células-Tronco Pluripotentes Induzidas / Células-Tronco Neurais Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genoma Humano / Adesão Celular / Regulação da Expressão Gênica / Astrócitos / Síndrome de Down / Células-Tronco Pluripotentes Induzidas / Células-Tronco Neurais Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article