Vesicular transport and secretion of penicillin G in Penicillium rubens P2-32-T.
Arch Microbiol
; 202(5): 1257-1262, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-31953549
ABSTRACT
The compartmentalization of penicillin G biosynthesis in Penicillium rubens has been extensively studied. However, how this compound is secreted has not been completely elucidated, although its transport could be of the vesicular type. This work was aimed at observing vesicles and penicillin secretion and proposing a hypothetical model for their compartmentalization and secretion. For this purpose, a high-penicillin-producing strain (P. rubens P2-32-T) was compared by transmission electron microscopy (TEM) and atomic force microscopy (AFM) with a null-producing strain (P. rubens npe10) in 24- and 48-h cultures. The results showed multivesicular bodies and secretory vesicles, suggesting that P. rubens transports and secretes penicillin G through vesicular excretion.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicilina G
/
Penicillium
/
Transporte Biológico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article