Visible-Light-Assisted Gold-Catalyzed Fluoroarylation of Allenoates.
Angew Chem Int Ed Engl
; 59(13): 5242-5247, 2020 Mar 23.
Article
em En
| MEDLINE
| ID: mdl-31953978
ABSTRACT
A strategically novel synthetic method for the fluoroarylation of allenic ester was developed that enables the expedient construction of a host of ß-fluoroalkyl-containing cinnamate derivatives. The reaction proceeds through visible-light-promoted gold redox catalysis, occurs smoothly under very mild reaction conditions, accommodates a large variety of functional groups, and more importantly allows the incorporation of fluorine and aryl groups with excellent regio- and stereoselectivity. The concomitant activation mode for both the allene motif and the hydrogen fluoride is key for the success of the reaction.
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Coleções:
01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article