Human papillomavirus insertions identify the PIM family of serine/threonine kinases as targetable driver genes in head and neck squamous cell carcinoma.

Broutian, Tatevik R; Jiang, Bo; Li, Jingfeng; Akagi, Keiko; Gui, Shanying; Zhou, Zhengqiu; Xiao, Weihong; Symer, David E; Gillison, Maura L

Broutian, Tatevik R; Jiang, Bo; Li, Jingfeng; Akagi, Keiko; Gui, Shanying; Zhou, Zhengqiu; Xiao, Weihong; Symer, David E; Gillison, Maura L.

Afiliação

Broutian TR; Biomedical Sciences Graduate Program, Ohio State University, Columbus, OH, 43210, United States.
Jiang B; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States.
Li J; Division of Medical Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH, 43210, United States.
Akagi K; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States.
Gui S; Division of Medical Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH, 43210, United States.
Zhou Z; Division of Medical Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH, 43210, United States.
Xiao W; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States.
Symer DE; Department of Lymphoma and Myeloma, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States. Electronic address: desymer@mdanderson.org.
Gillison ML; Department of Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, United States. Electronic address: mgillison@mdanderson.org.

Cancer Lett ; 476: 23-33, 2020 04 28.

Article em En | MEDLINE | ID: mdl-31958486

Assuntos

Neoplasias de Cabeça e Pescoço/genética; Papillomavirus Humano 16/genética; Infecções por Papillomavirus/complicações; Proteínas Proto-Oncogênicas c-pim-1/genética; Carcinoma de Células Escamosas de Cabeça e Pescoço/genética; Integração Viral/genética; Animais; Apoptose; Proliferação de Células; Feminino; Neoplasias de Cabeça e Pescoço/patologia; Neoplasias de Cabeça e Pescoço/virologia; Humanos; Camundongos; Camundongos Nus; Infecções por Papillomavirus/genética; Infecções por Papillomavirus/virologia; Prognóstico; Proteínas Proto-Oncogênicas c-pim-1/antagonistas & inibidores; Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia; Carcinoma de Células Escamosas de Cabeça e Pescoço/virologia; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Head and neck squamous cell carcinoma; Human papillomavirus (HPV); Molecular therapeutics; PIM serine/threonine kinases; Virus insertional mutagenesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Integração Viral / Infecções por Papillomavirus / Papillomavirus Humano 16 / Proteínas Proto-Oncogênicas c-pim-1 / Carcinoma de Células Escamosas de Cabeça e Pescoço / Neoplasias de Cabeça e Pescoço Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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