Inhibition of Frizzled-2 by small interfering RNA protects rat hepatic BRL-3A cells against cytotoxicity and apoptosis induced by Hypoxia/Reoxygenation.

Hu, Xiang; Zhou, Chenjie; He, Guolin; Cheng, Yuan; Pan, Mingxin; Gao, Yi

Hu, Xiang; Zhou, Chenjie; He, Guolin; Cheng, Yuan; Pan, Mingxin; Gao, Yi.

Afiliação

Hu X; Department of Hepatobiliary Surgery II, State Key Laboratory of Organ Failure Research, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital,
Zhou C; Department of Hepatobiliary Surgery II, State Key Laboratory of Organ Failure Research, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital,
He G; Department of Hepatobiliary Surgery II, State Key Laboratory of Organ Failure Research, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital,
Cheng Y; Department of Hepatobiliary Surgery II, State Key Laboratory of Organ Failure Research, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital,
Pan M; Department of Hepatobiliary Surgery II, State Key Laboratory of Organ Failure Research, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital,
Gao Y; Department of Hepatobiliary Surgery II, State Key Laboratory of Organ Failure Research, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital,

Gastroenterol Hepatol ; 43(3): 107-116, 2020 Mar.

Article em En, Es | MEDLINE | ID: mdl-31964521

Assuntos

Hipóxia Celular/efeitos dos fármacos; Hepatócitos/efeitos dos fármacos; Interferência de RNA; RNA Interferente Pequeno/farmacologia; Traumatismo por Reperfusão/prevenção & controle; Animais; Apoptose/efeitos dos fármacos; Sinalização do Cálcio/efeitos dos fármacos; Caspase 3/biossíntese; Caspase 3/genética; Hipóxia Celular/genética; Linhagem Celular; Receptores Frizzled/biossíntese; Receptores Frizzled/genética; Regulação da Expressão Gênica; Hepatócitos/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; RNA Interferente Pequeno/genética; Ratos; Traumatismo por Reperfusão/genética; Traumatismo por Reperfusão/metabolismo; Via de Sinalização Wnt/efeitos dos fármacos; Proteína Wnt-5a/biossíntese; Proteína Wnt-5a/genética; beta Catenina/biossíntese; beta Catenina/genética

Palavras-chave

ARNip; Apoptosis; Ca(2+) intracelular; Estudio de ratones in vivo; Frizzled-2; Hepatic BRL-3A cells; Hepatocitos BRL-3A; Hipoxia/reoxigenación; Hypoxia/Reoxygenation (H/R); In vivo mice study; Intracellular Ca(2+); siRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Hipóxia Celular / Hepatócitos / RNA Interferente Pequeno / Interferência de RNA Limite: Animals Idioma: En / Es Ano de publicação: 2020 Tipo de documento: Article

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