Combined Hydrophobization of Polyethylenimine with Cholesterol and Perfluorobutyrate Improves siRNA Delivery.

Wu, Pengkai; Luo, Xinping; Wu, Hui; Zhang, Qingyan; Wang, Kaikai; Sun, Minjie; Oupicky, David

Wu, Pengkai; Luo, Xinping; Wu, Hui; Zhang, Qingyan; Wang, Kaikai; Sun, Minjie; Oupicky, David.

Afiliação

Wu P; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Luo X; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.
Wu H; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Zhang Q; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Wang K; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Sun M; School of Pharmacy, Nantong University, Nantong 226001, China.
Oupicky D; State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.

Bioconjug Chem ; 31(3): 698-707, 2020 03 18.

Article em En | MEDLINE | ID: mdl-31967460

Assuntos

Colesterol/química; Portadores de Fármacos/química; Fluorocarbonos/química; Interações Hidrofóbicas e Hidrofílicas; Polietilenoimina/química; RNA Interferente Pequeno/química; Animais; Linhagem Celular Tumoral; Inativação Gênica; Camundongos; RNA Interferente Pequeno/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoimina / Portadores de Fármacos / Colesterol / RNA Interferente Pequeno / Interações Hidrofóbicas e Hidrofílicas / Fluorocarbonos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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