Photoactive metal complexes that bind DNA and other biomolecules as cell probes, therapeutics, and theranostics.
Chem Commun (Camb)
; 56(10): 1464-1480, 2020 Feb 04.
Article
em En
| MEDLINE
| ID: mdl-31967621
ABSTRACT
This review discusses the advantages of using luminescent d6-transition-metal complexes as cell probes for optical microscopy. In particular it focusses on the Thomas group's use of specific complexes as "building blocks" toward the construction of biomolecular binding substrates, with DNA being a particular target. Using this approach, a range of new imaging probes for conventional optical microscopy, nanoscopy and transmission electron microscopy have been identified. Through selection of specific metal centres and by substitution of coordinated ligands we illustrate how new chemotherapeutics, photo-therapeutics, and theranostics have been identified and developed from the original architectures.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Complexos de Coordenação
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article