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MPL mutations in essential thrombocythemia uncover a common path of activation with eltrombopag dependent on W491.
Levy, Gabriel; Carillo, Serge; Papoular, Benjamin; Cassinat, Bruno; Zini, Jean-Marc; Leroy, Emilie; Varghese, Leila N; Chachoua, Ilyas; Defour, Jean-Philippe; Smith, Steven O; Constantinescu, Stefan N.
Afiliação
  • Levy G; de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
  • Carillo S; Ludwig Institute for Cancer Research, Brussels, Belgium.
  • Papoular B; Walloon Excellence in Life Sciences and Biotechnology, Brussels, Belgium.
  • Cassinat B; Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
  • Zini JM; Laboratoire d'Histologie-Embryologie-Cytogénétique, Institut des Biomolécules Max Mousseron, Centre National de la Recherche Scientifique Unité Mixte de Recherche (UMR) 5247, Faculté de Médecine Montpellier-Nîmes, Université de Montpellier, Nîmes, France.
  • Leroy E; Department of Clinical Hematology, Faculté de Médecine Montpellier-Nîmes, University Hospital of Nîmes, Nîmes, France.
  • Varghese LN; Assistance Publique-Hôpitaux de Paris (APHP), Service de Biologie Cellulaire, Hôpital Saint-Louis, Paris, France.
  • Chachoua I; Institut de Recherche Saint-Louis, UMRS 1131 INSERM, Université de Paris, Paris, France.
  • Defour JP; APHP, Service d'Hématologie Clinique, Hôpital Saint-Louis, Paris, France.
  • Smith SO; de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
  • Constantinescu SN; Ludwig Institute for Cancer Research, Brussels, Belgium.
Blood ; 135(12): 948-953, 2020 03 19.
Article em En | MEDLINE | ID: mdl-31978223
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Benzoatos / Predisposição Genética para Doença / Receptores de Trombopoetina / Trombocitemia Essencial / Hidrazinas / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Benzoatos / Predisposição Genética para Doença / Receptores de Trombopoetina / Trombocitemia Essencial / Hidrazinas / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article