Inhibitory effects of aloin on TGFBIp-mediated septic responses.
J Asian Nat Prod Res
; 23(2): 189-203, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-31979986
ABSTRACT
Aloin is the major anthraquinone glycoside obtained from the Aloe species. Transforming growth factor ß-induced protein (TGFBIp) is an extracellular matrix protein and released by primary human umbilical vein endothelial cells (HUVECs) and functions as a mediator of experimental sepsis. We hypothesized that aloin could reduce TGFBIp-mediated severe inflammatory responses in HUVECs and mice. Aloin effectively inhibited lipopolysaccharide (LPS)-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. Aloin suppressed TGFBIp-induced sepsis lethality and pulmonary injury. Therefore, aloin is a potential therapeutic agent for various severe vascular inflammatory diseases, with inhibition of the TGFBIp signaling pathway as the mechanism of action. [Formula see text].
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas da Matriz Extracelular
/
Fator de Crescimento Transformador beta
Limite:
Animals
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article