O-GlcNAcylation of light chain serine 12 mediates rituximab production doubled by thiamet G.

Kim, Hye-Yeon; Park, Minseong; Kang, Choeun; Heo, Woon; Yoon, Sei Mee; Lee, Jinu; Kim, Joo Young

Kim, Hye-Yeon; Park, Minseong; Kang, Choeun; Heo, Woon; Yoon, Sei Mee; Lee, Jinu; Kim, Joo Young.

Afiliação

Kim HY; Department of Pharmacology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, 03080, Korea.
Park M; Department of Pharmacology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, 03080, Korea.
Kang C; Department of Pharmacology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, 03080, Korea.
Heo W; Department of Pharmacology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, 03080, Korea.
Yoon SM; College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 21983, Republic of Korea.
Lee J; College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, 21983, Republic of Korea. jinulee@yonsei.ac.kr.
Kim JY; Department of Pharmacology and Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, 03080, Korea. jooyoungkim@yuhs.ac.

Bioprocess Biosyst Eng ; 43(5): 863-875, 2020 May.

Article em En | MEDLINE | ID: mdl-31980903

Assuntos

Mutação de Sentido Incorreto; N-Acetilglucosaminiltransferases/antagonistas & inibidores; Piranos/farmacologia; Rituximab; Tiazóis/farmacologia; Substituição de Aminoácidos; Animais; Células CHO; Cricetulus; Glicosilação/efeitos dos fármacos; Humanos; N-Acetilglucosaminiltransferases/metabolismo; Rituximab/biossíntese; Rituximab/genética

Palavras-chave

ADCC; CDC; O-GlcNAc; Production yield; Rituximab; Thermal stability; Thiamet G

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piranos / Tiazóis / N-Acetilglucosaminiltransferases / Mutação de Sentido Incorreto / Rituximab Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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