Synthesis of chromone-containing polycyclic compounds via palladium-catalyzed [2 + 2 + 1] annulation.
Org Biomol Chem
; 18(6): 1112-1116, 2020 02 14.
Article
em En
| MEDLINE
| ID: mdl-31984976
ABSTRACT
A palladium-catalyzed [2 + 2 + 1] domino annulation of 3-iodochromones, α-bromo carbonyl compounds, and tetracyclododecene (TCD) is described. This approach provides a facile, efficient and atom-economical route to a variety of chromone-containing polycyclic compounds bearing fused/bridged-ring systems in good yields (up to 81%) with excellent diastereoselectivities (99 1 dr in all cases).
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2020
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Article