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Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice.
Shabalova, Anna A; Liang, Mingkun; Zhong, Jing; Huang, Zhiqi; Tsuji, Chiharu; Shnayder, Natalia A; Lopatina, Olga; Salmina, Alla B; Okamoto, Hiroshi; Yamamoto, Yasuhiko; Zhong, Zeng-Guo; Yokoyama, Shigeru; Higashida, Haruhiro.
Afiliação
  • Shabalova AA; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan; Department of Socioneurosciences, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University Schoo
  • Liang M; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan; Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China.
  • Zhong J; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan; Department of Physiology, Guangxi University of Chinese Medicine, Xianhu Campus, Nanning, Guangxi 530200, China.
  • Huang Z; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan; Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Xianhu Campus, Nanning, Guangxi 530200, China.
  • Tsuji C; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
  • Shnayder NA; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
  • Lopatina O; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan; Laboratory for Social Brain Studies, Research Institute of Molecular Medicine and Pathobiochemistry, Department of Biochemistry, Krasnoyarsk Sta
  • Salmina AB; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan; Laboratory for Social Brain Studies, Research Institute of Molecular Medicine and Pathobiochemistry, Department of Biochemistry, Krasnoyarsk Sta
  • Okamoto H; Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
  • Yamamoto Y; Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Sciences, Kanazawa 920-8640, Japan.
  • Zhong ZG; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan; Center of Research & Development of New Drugs, Guangxi Traditional Chinese Medical University, Guangxi Zhuang Autonomous Region, Nanning 530
  • Yokoyama S; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan.
  • Higashida H; Department of Basic Research on Social Recognition and Memory, Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan; Laboratory for Social Brain Studies, Research Institute of Molecular Medicine and Pathobiochemistry, Department of Biochemistry, Krasnoyarsk Sta
Horm Behav ; 120: 104695, 2020 04.
Article em En | MEDLINE | ID: mdl-31987898
In mammals, the development of healthy offspring requires maternal care. Behavior by lactating mothers toward other individuals is an important component of maternal aggression. However, it is unclear whether fathers display aggression primed by pups (an external factor), and the protection mechanism is poorly understood. To address this question, we examined paternal aggression in the ICR mouse strain. We found that sires exposed to cues from pups and lactating dams showed stronger aggression toward intruders than did sires that were deprived of family cues or exposed to nonlactating mates. c-Fos immunohistochemistry showed that cells in both the paraventricular and supraoptic nuclei (PVN and SON, respectively) in the hypothalamus of sires exposed to any cues were highly activated. However, c-Fos activation in oxytocinergic neurons was increased only in sires exposed to pup cues and solely in the PVN. In Cd38-knockout sires, the presence of pups induced no or reduced parental aggression; however, this phenotype was recovered, that is, aggression increased to the wild-type level, after intraperitoneal administration of oxytocin (OT). Specific c-Fos activation patterns induced by pup cues were not found in the PVN of knockout sires. These results demonstrate that the PVN is one of the primary hypothalamic areas involved in paternal aggression and suggest that a CD38-dependent OT mechanism in oxytocinergic neurons is critical for part of the behavior associated with the protection of offspring by nurturing male mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Hipotalâmico Paraventricular / Comportamento Paterno / Ocitocina / Glicoproteínas de Membrana / ADP-Ribosil Ciclase / Agressão / ADP-Ribosil Ciclase 1 Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Hipotalâmico Paraventricular / Comportamento Paterno / Ocitocina / Glicoproteínas de Membrana / ADP-Ribosil Ciclase / Agressão / ADP-Ribosil Ciclase 1 Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article