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Rapid fabrication of precise high-throughput filters from membrane protein nanosheets.
Tu, Yu-Ming; Song, Woochul; Ren, Tingwei; Shen, Yue-Xiao; Chowdhury, Ratul; Rajapaksha, Prasangi; Culp, Tyler E; Samineni, Laxmicharan; Lang, Chao; Thokkadam, Alina; Carson, Drew; Dai, Yuxuan; Mukthar, Arwa; Zhang, Miaoci; Parshin, Andrey; Sloand, Janna N; Medina, Scott H; Grzelakowski, Mariusz; Bhattacharya, Dibakar; Phillip, William A; Gomez, Enrique D; Hickey, Robert J; Wei, Yinai; Kumar, Manish.
Afiliação
  • Tu YM; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Song W; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
  • Ren T; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Shen YX; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
  • Chowdhury R; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Rajapaksha P; Department of Civil, Environmental, & Construction Engineering, Texas Tech University, Lubbock, TX, USA.
  • Culp TE; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Samineni L; Department of Chemistry, University of Kentucky, Lexington, KY, USA.
  • Lang C; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Thokkadam A; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Carson D; Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.
  • Dai Y; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Mukthar A; Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA, USA.
  • Zhang M; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ, USA.
  • Parshin A; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Sloand JN; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Medina SH; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA.
  • Grzelakowski M; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Bhattacharya D; Applied Biomimetic, Gaithersburg, MD, USA.
  • Phillip WA; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Gomez ED; Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
  • Hickey RJ; Applied Biomimetic, Gaithersburg, MD, USA.
  • Wei Y; Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY, USA.
  • Kumar M; Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN, USA.
Nat Mater ; 19(3): 347-354, 2020 03.
Article em En | MEDLINE | ID: mdl-31988513
ABSTRACT
Biological membranes are ideal for separations as they provide high permeability while maintaining high solute selectivity due to the presence of specialized membrane protein (MP) channels. However, successful integration of MPs into manufactured membranes has remained a significant challenge. Here, we demonstrate a two-hour organic solvent method to develop 2D crystals and nanosheets of highly packed pore-forming MPs in block copolymers (BCPs). We then integrate these hybrid materials into scalable MP-BCP biomimetic membranes. These MP-BCP nanosheet membranes maintain the molecular selectivity of the three types of ß-barrel MP channels used, with pore sizes of 0.8 nm, 1.3 nm, and 1.5 nm. These biomimetic membranes demonstrate water permeability that is 20-1,000 times greater than that of commercial membranes and 1.5-45 times greater than that of the latest research membranes with comparable molecular exclusion ratings. This approach could provide high performance alternatives in the challenging sub-nanometre to few-nanometre size range.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanoestruturas / Proteínas de Membrana / Membranas Artificiais Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanoestruturas / Proteínas de Membrana / Membranas Artificiais Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article