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hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation.
Batlle, Cristina; Yang, Peiguo; Coughlin, Maura; Messing, James; Pesarrodona, Mireia; Szulc, Elzbieta; Salvatella, Xavier; Kim, Hong Joo; Taylor, J Paul; Ventura, Salvador.
Afiliação
  • Batlle C; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autónoma de Barcelona, Bellaterra 08193, Spain.
  • Yang P; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Coughlin M; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Messing J; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 201815, USA.
  • Pesarrodona M; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Joint BSC-IRB Research Programme in Computational Biology, Baldiri Reixac 10, 08028 Barcelona, Spain.
  • Szulc E; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Joint BSC-IRB Research Programme in Computational Biology, Baldiri Reixac 10, 08028 Barcelona, Spain.
  • Salvatella X; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac 10, 08028 Barcelona, Spain; Joint BSC-IRB Research Programme in Computational Biology, Baldiri Reixac 10, 08028 Barcelona, Spain; ICREA, Passeig Lluís Companys 23, 08010 Barcelona
  • Kim HJ; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Taylor JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 201815, USA. Electronic address: jpaul.taylor@stjude.org.
  • Ventura S; Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autónoma de Barcelona, Bellaterra 08193, Spain. Electronic address: salvador.ventura@uab.cat.
Cell Rep ; 30(4): 1117-1128.e5, 2020 01 28.
Article em En | MEDLINE | ID: mdl-31995753
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Celular / Ribonucleoproteínas Nucleares Heterogêneas Grupo D / Distrofia Muscular do Cíngulo dos Membros / Drosophila / Proteínas Amiloidogênicas / Agregação Patológica de Proteínas Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleo Celular / Ribonucleoproteínas Nucleares Heterogêneas Grupo D / Distrofia Muscular do Cíngulo dos Membros / Drosophila / Proteínas Amiloidogênicas / Agregação Patológica de Proteínas Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article