PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.

Musiani, Daniele; Giambruno, Roberto; Massignani, Enrico; Ippolito, Marica Rosaria; Maniaci, Marianna; Jammula, Sriganesh; Manganaro, Daria; Cuomo, Alessandro; Nicosia, Luciano; Pasini, Diego; Bonaldi, Tiziana

Musiani, Daniele; Giambruno, Roberto; Massignani, Enrico; Ippolito, Marica Rosaria; Maniaci, Marianna; Jammula, Sriganesh; Manganaro, Daria; Cuomo, Alessandro; Nicosia, Luciano; Pasini, Diego; Bonaldi, Tiziana.

Afiliação

Musiani D; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Giambruno R; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Massignani E; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Ippolito MR; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Maniaci M; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Jammula S; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Manganaro D; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Cuomo A; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Nicosia L; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy.
Pasini D; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy; Department of Health Sciences, University of Milan, Milan, Italy.
Bonaldi T; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy. Electronic address: tiziana.bonaldi@ieo.it.

Cell Rep ; 30(4): 1208-1222.e9, 2020 01 28.

Article em En | MEDLINE | ID: mdl-31995759

Assuntos

Antineoplásicos/farmacologia; Senescência Celular/efeitos dos fármacos; Cromatina/metabolismo; Cisplatino/farmacologia; Proteína Quinase Ativada por DNA/metabolismo; Proteína-Arginina N-Metiltransferases/metabolismo; Proteínas Repressoras/metabolismo; Arginina/metabolismo; Senescência Celular/genética; Imunoprecipitação da Cromatina; Cromatografia Líquida; Dano ao DNA/efeitos dos fármacos; Dano ao DNA/efeitos da radiação; Proteína Quinase Ativada por DNA/genética; Células HEK293; Células HeLa; Histonas/metabolismo; Humanos; Espectrometria de Massas; Metilação; NF-kappa B/metabolismo; Proteína-Arginina N-Metiltransferases/antagonistas & inibidores; Proteína-Arginina N-Metiltransferases/genética; Proteoma/química; Proteoma/metabolismo; RNA-Seq; Proteínas Repressoras/antagonistas & inibidores; Proteínas Repressoras/genética; Espectrometria de Massas em Tandem

Palavras-chave

DNA-PK; MS-based proteomics; PRMT1; SASP; arginine methylation; cisplatin; epigenetic drugs; replication stress response; transcription

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteína-Arginina N-Metiltransferases / Proteínas Repressoras / Cromatina / Cisplatino / Senescência Celular / Proteína Quinase Ativada por DNA / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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