Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate.

Kolwicz, Stephen C; Hall, John K; Moussavi-Harami, Farid; Chen, Xiolan; Hauschka, Stephen D; Chamberlain, Jeffrey S; Regnier, Michael; Odom, Guy L

Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate.

Kolwicz, Stephen C; Hall, John K; Moussavi-Harami, Farid; Chen, Xiolan; Hauschka, Stephen D; Chamberlain, Jeffrey S; Regnier, Michael; Odom, Guy L.

Afiliação

Kolwicz SC; Mitochondria and Metabolism Center, University of Washington, Seattle, Washington.
Hall JK; Department of Neurology, University of Washington, Seattle, Washington.
Moussavi-Harami F; Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington.
Chen X; Department of Biochemistry, University of Washington, Seattle, Washington.
Hauschka SD; Wellstone Muscular Dystrophy Specialized Research Center, University of Washington, Seattle, Washington.
Chamberlain JS; Department of Biochemistry, University of Washington, Seattle, Washington.
Regnier M; Wellstone Muscular Dystrophy Specialized Research Center, University of Washington, Seattle, Washington.
Odom GL; Department of Neurology, University of Washington, Seattle, Washington.

JACC Basic Transl Sci ; 4(7): 778-791, 2019 Nov.

Article em En | MEDLINE | ID: mdl-31998848

Palavras-chave

CK8, miniaturized murine creatine kinase regulatory cassette; CMV, cytomegalovirus; DMD, Duchenne muscular dystrophy; RNR, ribonucleotide reductase; cTnT, cardiac troponin T; cardiomyopathy; dADP, deoxy-adenosine diphosphate; dATP, deoxy-adenosine triphosphate; diastolic dysfunction; dystrophin; mdx, mouse muscular dystrophy model; rAAV, recombinant adeno-associated viral vector; recombinant adeno-associated virus vectors; ribonucleotide reductase; µDys, microdystrophin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2019 Tipo de documento: Article