Evaluation of pre- and post-fusion Human metapneumovirus F proteins as subunit vaccine candidates in mice.
Vaccine
; 38(9): 2122-2127, 2020 02 24.
Article
em En
| MEDLINE
| ID: mdl-32007293
ABSTRACT
Human metapneumovirus (hMPV) is an important respiratory pathogen especially in young children and elderly subjects. Our objective was to assess the immunogenicity and protection conferred by predominant pre- and post-fusion (F) hMPV-F constructs in Balb/C mice. Immunizations without adjuvant were not immunogenic whereas alum-adjuvanted hMPV-F proteins, regardless of their conformations, generated comparable neutralizing antibody titers with undetectable pulmonary viral titers following viral challenge. In conclusion, we found no apparent advantage for mixtures of predominant pre-fusion F proteins over post-fusion conformations for hMPV vaccination in opposite to recent data obtained with the human respiratory syncytial virus.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
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Proteínas Virais de Fusão
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Adjuvantes Imunológicos
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Infecções por Paramyxoviridae
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Metapneumovirus
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article