Rational Design of a Cocktail of Inhibitors against Aß Aggregation.
Chemistry
; 26(16): 3499-3503, 2020 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-32011042
ABSTRACT
It has been reported that many molecules could inhibit the aggregation of Aß (amyloid-ß) through suppressing either primary nucleation, secondary nucleation, or elongation processes. In order to suppress multiple pathways of Aß aggregation, we screened 23 small molecules and found two types of inhibitors with different inhibiting mechanisms based on chemical kinetics analysis. Trp-glucose conjugates (AS2) could bind with fibril ends while natural products (D3 and D4) could associate with monomers. A cocktail of these two kinds of molecules achieved co-inhibition of various fibrillar species and avoid unwanted interference.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Peptídeos beta-Amiloides
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article