Anticoagulation reversal for intracranial hemorrhage in the era of the direct oral anticoagulants.
Curr Opin Crit Care
; 26(2): 122-128, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32022724
ABSTRACT
PURPOSE OF REVIEW This review focuses on recent relevant literature that examines the reversal of direct oral anticoagulants (DOACs) in patients with intracranial hemorrhage (ICH). The aim of this review is to provide an insightful description of available reversal agents and their clinical utility. RECENT FINDINGS:
Increases in prescribing of DOACs has led to the introduction of drug-specific reversal agents. The clinical trials that evaluated these agents did not include a comparator arm making it difficult to determine if they are clinically superior to nonspecific reversal agents.SUMMARY:
Numerous options for reversal of DOAC-associated ICH are currently available. Recent clinical trials have demonstrated drug-specific reversal agents are effective in this setting, but additional research is needed to determine whether these agents should be routinely preferred over nonspecific reversal agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemorragias Intracranianas
/
Anticoagulantes
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article