Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation.
Curr Opin Neurobiol
; 62: 83-91, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32028080
ABSTRACT
The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and immunity. The mechanisms underlying the formation of gastrointestinal neurons are beginning to be elucidated; those that keep them plastic over an organism's lifetime remain to be explored. Here, we review the effects of microbiota, nutrients, sex and ageing on the morphology and function of gastrointestinal innervation in mammals, and discuss how this plasticity shapes gut-brain crosstalk and whole-body physiology. We also highlight insights gained by nascent studies of the enteric innervation of Drosophila melanogaster.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Entérico
/
Trato Gastrointestinal
/
Fenômenos Fisiológicos do Sistema Nervoso
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article