Risk of diabetic complications and subsequent mortality among individuals with schizophrenia and diabetes - a population-based register study.
Schizophr Res
; 218: 99-106, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32029352
ABSTRACT
BACKGROUND:
Individuals with schizophrenia often develop diabetes, but little is known about their risk of diabetic complications. We aimed to study incidence of registered diabetic complications and subsequent mortality in individuals with schizophrenia and diabetes compared to individuals with diabetes only.METHODS:
We conducted a cohort study using nationwide registers and followed all individuals in the entire Danish population diagnosed with diabetes from 1997 to 2017. Incidence rate ratios (IRR) of diabetic complications, all-cause and cause-specific mortality rate ratios (MRR) were estimated by Cox regression comparing individuals diagnosed with schizophrenia and diabetes to individuals diagnosed only with diabetes.RESULTS:
In a cohort of 239,118 individuals with diagnosed diabetes, the incidence of any diabetic complication was similar in females with schizophrenia and diabetes compared to females with diabetes only; IRRâ¯=â¯0.93 (95%CI 0.84-1.02), and significantly lower in males; IRRâ¯=â¯0.85 (95%CI 0.78-0.92). The all-cause mortality for individuals with a diagnosis of a diabetic complication was higher in individuals with schizophrenia and diabetes than in those with diabetes only; MRRâ¯=â¯1.92 (95%CI 1.65-2.23) for females and MRRâ¯=â¯1.69 (95%CI 1.49-1.92) for males. Among those without diabetic complications, schizophrenia was also associated with a higher mortality.CONCLUSIONS:
Individuals with schizophrenia and diabetes had similar or lower rates of diabetic complications, compared to those with diabetes only. Among those with diabetic complications, schizophrenia was associated with higher mortality. Similar, among those without diabetic complications, schizophrenia was also associated with higher mortality. Hence, diabetic complications do not seem to explain the excess mortality seen in individuals with schizophrenia.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Complicações do Diabetes
/
Diabetes Mellitus
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article