Predictors of asynchronies during assisted ventilation and its impact on clinical outcomes: The EPISYNC cohort study.
J Crit Care
; 57: 30-35, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32032901
ABSTRACT
PURPOSE:
To investigate if respiratory mechanics and other baseline characteristics are predictors of patient-ventilator asynchrony and to evaluate the relationship between asynchrony during assisted ventilation and clinical outcomes.METHODS:
We performed a prospective cohort study in patients under mechanical ventilation (MV). Baseline measurements included severity of illness and respiratory mechanics. The primary outcome was the Asynchrony Index (AI), defined as the number of asynchronous events divided by the number of ventilator cycles and wasted efforts. We recorded ventilator waveforms throughout the entire period of MV.RESULTS:
We analyzed 11,881â¯h of MV from 103 subjects. Median AI during the entire period of MV was 5.1% (IQR2.6-8.7). Intrinsic PEEP was associated with AI (OR1.72, 95%CI1.1-2.68), but static compliance and airway resistance were not. Simplified Acute Physiology Score 3 (OR1.03, 95%CI1-1.06) was also associated with AI. Median AI was higher during assisted (5.4%, IQR2.9-9.1) than controlled (2%, IQR0.6-4.9) ventilation, and 22% of subjects had high incidence of asynchrony (AI≥10%). Subjects with AI≥10% had more extubation failure (33%) than patients with AI<10% (6%), pâ¯=â¯.01.CONCLUSIONS:
Predictors of high incidence of asynchrony were severity of illness and intrinsic PEEP. High incidence of asynchrony was associated with extubation failure, but not mortality. TRIAL REGISTRATION ClinicalTrials.gov, NCT02687802.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Respiração Artificial
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Ventiladores Mecânicos
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Mecânica Respiratória
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Respiração com Pressão Positiva
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article