Radiosensitizing effect of camphor on transplantable mammary adenocarcinoma in mice.
Cancer Lett
; 43(1-2): 21-7, 1988 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-3203326
ABSTRACT
The comparative radiosensitizing effects of camphor and metronidazole on murine transplantable mammary adenocarcinoma are reported. Male C3H/Jax mice bearing transplanted mammary tumours were treated with camphor (0.5 microM/body wt) or metronidazole (0.5 microM/g body wt) 45 min before subjecting to local X-irradiation at the dose levels of 30, 80, 100 or 120 Gy. Sequential in situ measurement of the tumour volumes during the follow-up period of 45 days revealed that the maximum enhancement ratios of tumour growth delay for camphor and metronidazole were 4.8 and 2.5, respectively. This suggests that camphor can be a potential radiosensitizing agent in cancer radiotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radiossensibilizantes
/
Cânfora
/
Adenocarcinoma
/
Neoplasias Mamárias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article