The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro.

Giustarini, Giulio; Huppelschoten, Suzanna; Barra, Marco; Oppelt, Angela; Wagenaar, Laura; Weaver, Richard J; Bol-Schoenmakers, Marianne; Smit, Joost J; van de Water, Bob; Klingmüller, Ursula; Pieters, Raymond H H

Giustarini, Giulio; Huppelschoten, Suzanna; Barra, Marco; Oppelt, Angela; Wagenaar, Laura; Weaver, Richard J; Bol-Schoenmakers, Marianne; Smit, Joost J; van de Water, Bob; Klingmüller, Ursula; Pieters, Raymond H H.

Afiliação

Giustarini G; Immunotoxicology, Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address: g.giustarini@uu.nl.
Huppelschoten S; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Barra M; Immunotoxicology, Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands; University of Pisa, Department of Pharmacy, Italy.
Oppelt A; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Wagenaar L; Immunotoxicology, Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Weaver RJ; Biopharmacy, Institut de Recherches Internationales Servier (I.R.I.S.), Suresnes 92284, France.
Bol-Schoenmakers M; Immunotoxicology, Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
Smit JJ; Immunotoxicology, Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.
van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Klingmüller U; Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pieters RHH; Immunotoxicology, Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address: r.h.h.pieters@uu.nl.

Toxicol Appl Pharmacol ; 391: 114915, 2020 03 15.

Article em En | MEDLINE | ID: mdl-32035082

Assuntos

Antibacterianos/toxicidade; Doença Hepática Induzida por Substâncias e Drogas/patologia; Fluoroquinolonas/toxicidade; Lipopolissacarídeos/farmacologia; Naftiridinas/toxicidade; Fator de Transcrição RelA/efeitos dos fármacos; Fator de Transcrição RelA/genética; Translocação Genética/efeitos dos fármacos; Fator de Necrose Tumoral alfa/farmacologia; Animais; Apoptose/efeitos dos fármacos; Doença Hepática Induzida por Substâncias e Drogas/genética; Citocinas/metabolismo; Humanos; Proteínas I-kappa B/metabolismo; Camundongos; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Células RAW 264.7; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Drug-induced liver injury; Inflammation; LPS; NF-κB; TNF; Trovafloxacin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Translocação Genética / Lipopolissacarídeos / Fator de Necrose Tumoral alfa / Fluoroquinolonas / Fator de Transcrição RelA / Doença Hepática Induzida por Substâncias e Drogas / Antibacterianos / Naftiridinas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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