Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements.
JACC Basic Transl Sci
; 5(1): 15-31, 2020 Jan.
Article
em En
| MEDLINE
| ID: mdl-32043018
ABSTRACT
This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell-scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.
B-GLAP, bone gamma-carboxyglutamate; BMMNC, bone marrow mononuclear cells; BVG, bioresorbable vascular graft; CXCL12, stromal cell-derived factor-1α (SDF1α); ECM, extracellular matrix; IL, interleukin; MCP, monocyte chemoattractant protein; MMP, matrix metalloproteinase; PC-BU, polycarbonate bisurea; SMA, smooth muscle actin; TEE, transesophageal echocardiography; TEHV, tissue-engineered heart valve; TGF, transforming growth factor; TVR, transcatheter valve replacement; cardiovascular regenerative medicine; endogenous tissue regeneration; in situ tissue engineering; supramolecular polymer; tissue-engineered heart valve
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01-internacional
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MEDLINE
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En
Ano de publicação:
2020
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Article