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Differential Leaflet Remodeling of Bone Marrow Cell Pre-Seeded Versus Nonseeded Bioresorbable Transcatheter Pulmonary Valve Replacements.
Fioretta, Emanuela S; Lintas, Valentina; Mallone, Anna; Motta, Sarah E; von Boehmer, Lisa; Dijkman, Petra E; Cesarovic, Nikola; Caliskan, Etem; Rodriguez Cetina Biefer, Héctor; Lipiski, Miriam; Sauer, Mareike; Putti, Matilde; Janssen, Henk M; Söntjens, Serge H; Smits, Anthal I P M; Bouten, Carlijn V C; Emmert, Maximilian Y; Hoerstrup, Simon P.
Afiliação
  • Fioretta ES; Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
  • Lintas V; Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
  • Mallone A; Wyss Translational Center Zürich, University of Zürich and ETH Zürich, Zürich, Switzerland.
  • Motta SE; Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
  • von Boehmer L; Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
  • Dijkman PE; Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
  • Cesarovic N; Institute for Regenerative Medicine, University of Zürich, Zürich, Switzerland.
  • Caliskan E; Division of Surgical Research, University of Zürich, Zürich, Switzerland.
  • Rodriguez Cetina Biefer H; Department of Cardiovascular Surgery, University Hospital Zürich, Zürich, Switzerland.
  • Lipiski M; Department of Cardiovascular Surgery, Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Sauer M; Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
  • Putti M; Department of Cardiovascular Surgery, University Hospital Zürich, Zürich, Switzerland.
  • Janssen HM; Division of Surgical Research, University of Zürich, Zürich, Switzerland.
  • Söntjens SH; Division of Surgical Research, University of Zürich, Zürich, Switzerland.
  • Smits AIPM; Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • Bouten CVC; Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands.
  • Emmert MY; SyMO-Chem B.V., Eindhoven, the Netherlands.
  • Hoerstrup SP; SyMO-Chem B.V., Eindhoven, the Netherlands.
JACC Basic Transl Sci ; 5(1): 15-31, 2020 Jan.
Article em En | MEDLINE | ID: mdl-32043018
ABSTRACT
This study showed that bone marrow mononuclear cell pre-seeding had detrimental effects on functionality and in situ remodeling of bioresorbable bisurea-modified polycarbonate (PC-BU)-based tissue-engineered heart valves (TEHVs) used as transcatheter pulmonary valve replacement in sheep. We also showed heterogeneous valve and leaflet remodeling, which affects PC-BU TEHV safety, challenging their potential for clinical translation. We suggest that bone marrow mononuclear cell pre-seeding should not be used in combination with PC-BU TEHVs. A better understanding of cell-scaffold interaction and in situ remodeling processes is needed to improve transcatheter valve design and polymer absorption rates for a safe and clinically relevant translation of this approach.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article