Beta-cell M<sub>3</sub> muscarinic acetylcholine receptors as potential targets for novel antidiabetic drugs.

Zhu, Lu; Rossi, Mario; Doliba, Nicolai M; Wess, Jürgen

Beta-cell M₃ muscarinic acetylcholine receptors as potential targets for novel antidiabetic drugs.

Zhu, Lu; Rossi, Mario; Doliba, Nicolai M; Wess, Jürgen.

Afiliação

Zhu L; Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Rossi M; Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Doliba NM; Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Wess J; Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: jurgenw@niddk.nih.gov.

Int Immunopharmacol ; 81: 106267, 2020 Apr.

Article em En | MEDLINE | ID: mdl-32044662

Assuntos

Acetilcolina/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Células Secretoras de Insulina/metabolismo; Receptor Muscarínico M3/metabolismo; Receptores Colinérgicos/metabolismo; Regulação Alostérica; Animais; Diabetes Mellitus Tipo 2/terapia; Humanos; Insulina/metabolismo; Células Secretoras de Insulina/patologia; Terapia de Alvo Molecular

Palavras-chave

Acetylcholine; Allosteric modulator; Beta-cell; Diabetes; G protein-coupled receptor; Insulin release; Muscarinic receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolina / Receptores Colinérgicos / Receptor Muscarínico M3 / Diabetes Mellitus Tipo 2 / Células Secretoras de Insulina Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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