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Nerve growth factor in the psychiatric brain.
Ciafrè, Stefania; Ferraguti, Giampiero; Tirassa, Paola; Iannitelli, Angela; Ralli, Massimo; Greco, Antonio; Chaldakov, George N; Rosso, Pamela; Fico, Elena; Messina, Marisa Patrizia; Carito, Valentina; Tarani, Luigi; Ceccanti, Mauro; Fiore, Marco.
Afiliação
  • Ciafrè S; Institute of Translational Pharmacology, IFT-CNR, Institute of Cell Biology and Neurobiology, IBCN-CNR, Rome, Italy.
  • Ferraguti G; Department of Experimental Medicine, Sapienza University of Rome, Italy.
  • Tirassa P; Institute of Biochemistry and Cell Biology, IBBC-CNR, Rome, Italy.
  • Iannitelli A; Department of Biotechnology and Applied Clinical Sciences, University of L'Aquila, Italy.
  • Ralli M; Department of Sense Organs, Sapienza University of Rome, Italy.
  • Greco A; Department of Sense Organs, Sapienza University of Rome, Italy.
  • Chaldakov GN; Department of Anatomy and Cell Biology, Medical University, Varna, Bulgaria.
  • Rosso P; Department of Experimental Medicine, Sapienza University of Rome, Italy.
  • Fico E; Department of Experimental Medicine, Sapienza University of Rome, Italy.
  • Messina MP; Department of Gynecology, Obstetric, and Urology, Sapienza University of Rome, Italy.
  • Carito V; Department of Experimental Medicine, Sapienza University of Rome, Italy.
  • Tarani L; Department of Pediatrics, Medical Faculty, Sapienza University of Rome, Italy.
  • Ceccanti M; Centro Riferimento Alcologico Regione Lazio, ASL Roma 1, Rome, Italy.
  • Fiore M; Department of Experimental Medicine, Sapienza University of Rome, Italy.
Riv Psichiatr ; 55(1): 4-15, 2020.
Article em En | MEDLINE | ID: mdl-32051620
ABSTRACT
The nerve growth factor (NGF) belongs to a family of proteins named neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. NGF regulates a large number of physiological mechanisms that result in neurotrophic, metabotrophic and/or immunotrophic effects. Neurodegenerative diseases, including Alzheimer disease, psychiatric disorders (e.g. depression and schizophrenia) and brain parasitic infection have in common the effect of changing the brain levels of neurotrophins, in particular NGF. The contribution of both NGF and its receptor TrkA in such events and the recent promising results of NGF based therapies are here presented and discussed.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Neural Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Neural Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article