Transcription factor AP2 controls cnidarian germ cell induction.
Science
; 367(6479): 757-762, 2020 02 14.
Article
em En
| MEDLINE
| ID: mdl-32054756
ABSTRACT
Clonal animals do not sequester a germ line during embryogenesis. Instead, they have adult stem cells that contribute to somatic tissues or gametes. How germ fate is induced in these animals, and whether this process is related to bilaterian embryonic germline induction, is unknown. We show that transcription factor AP2 (Tfap2), a regulator of mammalian germ lines, acts to commit adult stem cells, known as i-cells, to the germ cell fate in the clonal cnidarian Hydractinia symbiolongicarpus Tfap2 mutants lacked germ cells and gonads. Transplanted wild-type cells rescued gonad development but not germ cell induction in Tfap2 mutants. Forced expression of Tfap2 in i-cells converted them to germ cells. Therefore, Tfap2 is a regulator of germ cell commitment across germ line-sequestering and germ line-nonsequestering animals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrozoários
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Fator de Transcrição AP-2
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Células-Tronco Adultas
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Gametogênese
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Células Germinativas
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Gônadas
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article