Better influenza vaccines: an industry perspective.
J Biomed Sci
; 27(1): 33, 2020 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-32059697
ABSTRACT
Vaccination is the most effective measure at preventing influenza virus infections. However, current seasonal influenza vaccines are only protective against closely matched circulating strains. Even with extensive monitoring and annual reformulation our efforts remain one step behind the rapidly evolving virus, often resulting in mismatches and low vaccine effectiveness. Fortunately, many next-generation influenza vaccines are currently in development, utilizing an array of innovative techniques to shorten production time and increase the breadth of protection. This review summarizes the production methods of current vaccines, recent advances that have been made in influenza vaccine research, and highlights potential challenges that are yet to be overcome. Special emphasis is put on the potential role of glycoengineering in influenza vaccine development, and the advantages of removing the glycan shield on influenza surface antigens to increase vaccine immunogenicity. The potential for future development of these novel influenza vaccine candidates is discussed from an industry perspective.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
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Vacinas contra Influenza
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Glicoproteínas
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Engenharia de Proteínas
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Imunogenicidade da Vacina
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article