The Role of Extracellular DNA and Histones in Ischaemia-Reperfusion Injury of the Myocardium.
Cardiovasc Drugs Ther
; 34(1): 123-131, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-32062794
ABSTRACT
Despite an increase in the rates of survival in patients suffering myocardial infarction, as yet there is no therapy specifically targeting ischaemia and reperfusion injury of the myocardium. With a greater understanding of immune activation during infarction, more potential treatment targets are now being identified. The innate immune system is believed to play an important role in the myocardium after ischaemia-driven cardiomyocyte death. The release of intracellular contents including DNA into the extracellular space during necrosis and cell rupture is now believed to create a pro-inflammatory milieu which propagates the inflammatory process. DNA and DNA fragments have been shown to activate the innate immune system by acting as Danger-Associated Molecular Patterns (DAMPs), which act as ligands on toll-like receptors (TLRs). Stimulation of TLRs, in turn, can activate intracellular cell death pathways such as pyroptosis. Here, we review the role of DNA fragments during ischaemia and reperfusion, and assess their potential as a target in the quest to preserve cardiomyocyte viability following myocardial infarction.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
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Histonas
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Traumatismo por Reperfusão Miocárdica
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Alarminas
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Ácidos Nucleicos Livres
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Imunidade Inata
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Infarto do Miocárdio
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Miocárdio
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article