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Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability.
Guedan, Sonia; Madar, Aviv; Casado-Medrano, Victoria; Shaw, Carolyn; Wing, Anna; Liu, Fang; Young, Regina M; June, Carl H; Posey, Avery D.
Afiliação
  • Guedan S; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Madar A; Department of Hematology, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
  • Casado-Medrano V; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA.
  • Shaw C; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wing A; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Liu F; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Young RM; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • June CH; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Posey AD; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Clin Invest ; 130(6): 3087-3097, 2020 06 01.
Article em En | MEDLINE | ID: mdl-32069268
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoterapia Adotiva / Antígenos CD28 / Células Th17 / Receptores de Antígenos Quiméricos / Imunidade Celular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoterapia Adotiva / Antígenos CD28 / Células Th17 / Receptores de Antígenos Quiméricos / Imunidade Celular / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article