A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in <i>AKT1 E17K</i> Mutated Tumours.

Adams, Claire L; Ercolano, Emanuela; Ferluga, Sara; Sofela, Agbolahan; Dave, Foram; Negroni, Caterina; Kurian, Kathreena M; Hilton, David A; Hanemann, C Oliver

A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours.

Adams, Claire L; Ercolano, Emanuela; Ferluga, Sara; Sofela, Agbolahan; Dave, Foram; Negroni, Caterina; Kurian, Kathreena M; Hilton, David A; Hanemann, C Oliver.

Afiliação

Adams CL; Faculty of Health: Medicine, Dentistry and Human Sciences, The Institute of Translational and Stratified Medicine, University of Plymouth, The John Bull Building, Plymouth Science Park, Research Way, Plymouth PL6 8BU, UK.
Ercolano E; Faculty of Health: Medicine, Dentistry and Human Sciences, The Institute of Translational and Stratified Medicine, University of Plymouth, The John Bull Building, Plymouth Science Park, Research Way, Plymouth PL6 8BU, UK.
Ferluga S; Faculty of Health: Medicine, Dentistry and Human Sciences, The Institute of Translational and Stratified Medicine, University of Plymouth, The John Bull Building, Plymouth Science Park, Research Way, Plymouth PL6 8BU, UK.
Sofela A; Faculty of Health: Medicine, Dentistry and Human Sciences, The Institute of Translational and Stratified Medicine, University of Plymouth, The John Bull Building, Plymouth Science Park, Research Way, Plymouth PL6 8BU, UK.
Dave F; Department of Neurosurgery, University Hospitals Plymouth NHS Trust, Derriford Road, Plymouth PL6 8DH, UK.
Negroni C; Faculty of Health: Medicine, Dentistry and Human Sciences, The Institute of Translational and Stratified Medicine, University of Plymouth, The John Bull Building, Plymouth Science Park, Research Way, Plymouth PL6 8BU, UK.
Kurian KM; Faculty of Health: Medicine, Dentistry and Human Sciences, The Institute of Translational and Stratified Medicine, University of Plymouth, The John Bull Building, Plymouth Science Park, Research Way, Plymouth PL6 8BU, UK.
Hilton DA; Institute of Clinical Neuroscience, University of Bristol and Southmead Hospital, North Bristol Trust, Bristol BS8 1QU, UK.
Hanemann CO; Cellular and Anatomical Pathology, University Hospitals Plymouth NHS Trust, Derriford Road, Plymouth PL6 8DH, UK.

Int J Mol Sci ; 21(4)2020 Feb 13.

Article em En | MEDLINE | ID: mdl-32070062

Assuntos

Macrófagos/metabolismo; Meningioma/genética; Proteínas Proto-Oncogênicas c-akt/genética; Microambiente Tumoral/genética; Alelos; Antígenos CD/genética; Antígenos de Diferenciação Mielomonocítica/genética; Linhagem da Célula/genética; Feminino; Genótipo; Antígenos HLA-DR/genética; Humanos; Antígenos Comuns de Leucócito/genética; Receptores de Lipopolissacarídeos/genética; Macrófagos/classificação; Macrófagos/patologia; Masculino; Meningioma/classificação; Meningioma/patologia; Pessoa de Meia-Idade; Mutação/genética; Neurofibromina 2/genética; Receptores de Superfície Celular/genética

Palavras-chave

AKT1 E17K; M2 macrophage; NF2; genotype; meningioma; non-NF2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas c-akt / Microambiente Tumoral / Macrófagos / Meningioma Tipo de estudo: Diagnostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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