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Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α.
Melo, Helen M; Seixas da Silva, Gisele da S; Sant'Ana, Marcella Ramos; Teixeira, Camila Vieira Ligo; Clarke, Julia R; Miya Coreixas, Vivian S; de Melo, Bruno C; Fortuna, Juliana T S; Forny-Germano, Leticia; Ledo, José Henrique; Oliveira, Maíra S; Figueiredo, Claudia P; Pardossi-Piquard, Raphaelle; Checler, Frédéric; Delgado-García, José María; Gruart, Agnès; Velloso, Licio A; Balthazar, Marcio L F; Cintra, Dennys E; Ferreira, Sergio T; De Felice, Fernanda G.
Afiliação
  • Melo HM; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • Seixas da Silva GDS; Federal Institute of Education, Science and Technology of Rio de Janeiro, Rio de Janeiro, RJ 20270-021, Brazil.
  • Sant'Ana MR; Laboratory of Nutritional Genomics (LabGeN), School of Applied Sciences and CELN - Nutrigenomics and Lipids Research Center, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, SP 13484-350, Brazil.
  • Teixeira CVL; Brazilian Institute of Neuroscience and Neurotechnology (BRAINN) and Department of Neurology, Neuroimaging Laboratory, University of Campinas (UNICAMP), Campinas, SP 13083-887, Brazil.
  • Clarke JR; School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • Miya Coreixas VS; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • de Melo BC; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • Fortuna JTS; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • Forny-Germano L; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • Ledo JH; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • Oliveira MS; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • Figueiredo CP; School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • Pardossi-Piquard R; Université Côte d'Azur, INSERM, CNRS/UMR7275, IPMC, team labeled "Laboratory of Excellence (LABEX) Distalz," 660 route des Lucioles, 06560 Sophia-Antipolis, Valbonne, France.
  • Checler F; Université Côte d'Azur, INSERM, CNRS/UMR7275, IPMC, team labeled "Laboratory of Excellence (LABEX) Distalz," 660 route des Lucioles, 06560 Sophia-Antipolis, Valbonne, France.
  • Delgado-García JM; Division of Neuroscience, Pablo de Olavide University, Seville 41013, Spain.
  • Gruart A; Division of Neuroscience, Pablo de Olavide University, Seville 41013, Spain.
  • Velloso LA; Laboratory of Cell Signalling, Obesity and Comorbidities Research Centre, University of Campinas, Campinas, SP 13084-761, Brazil.
  • Balthazar MLF; Brazilian Institute of Neuroscience and Neurotechnology (BRAINN) and Department of Neurology, Neuroimaging Laboratory, University of Campinas (UNICAMP), Campinas, SP 13083-887, Brazil.
  • Cintra DE; Laboratory of Nutritional Genomics (LabGeN), School of Applied Sciences and CELN - Nutrigenomics and Lipids Research Center, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, SP 13484-350, Brazil.
  • Ferreira ST; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.
  • De Felice FG; Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; Centre for Neuroscience Studies and Department of Psychiatry, Queen's University, Kingston, ON K7L 3N6, Canada. Electronic address: felice@bioqmed.ufrj.br.
Cell Rep ; 30(7): 2180-2194.e8, 2020 02 18.
Article em En | MEDLINE | ID: mdl-32075735
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitatos / Fator de Necrose Tumoral alfa / Transtornos da Memória / Obesidade Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Palmitatos / Fator de Necrose Tumoral alfa / Transtornos da Memória / Obesidade Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article