Impairment of PGC-1&#945;-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease.

Singulani, Monique Patricio; Pereira, Carolina Parga Martins; Ferreira, Ana Flávia Fernandes; Garcia, Priscila Crespo; Ferrari, Gustavo Duarte; Alberici, Luciane Carla; Britto, Luiz Roberto

Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease.

Singulani, Monique Patricio; Pereira, Carolina Parga Martins; Ferreira, Ana Flávia Fernandes; Garcia, Priscila Crespo; Ferrari, Gustavo Duarte; Alberici, Luciane Carla; Britto, Luiz Roberto.

Afiliação

Singulani MP; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: moniquesingulani@gmail.com.
Pereira CPM; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Ferreira AFF; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Garcia PC; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Ferrari GD; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Alberici LC; Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
Britto LR; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address: britto@icb.usp.br.

Exp Gerontol ; 133: 110882, 2020 05.

Article em En | MEDLINE | ID: mdl-32084533

Assuntos

Doença de Alzheimer; Biogênese de Organelas; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Doença de Alzheimer/genética; Animais; Complexo IV da Cadeia de Transporte de Elétrons/metabolismo; Camundongos; Mitocôndrias/metabolismo; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/genética; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo

Palavras-chave

3xTg-AD; Alzheimer's disease; Mitochondria dysfunction; Mitochondrial biogenesis; PGC-1α

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biogênese de Organelas / Doença de Alzheimer / Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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