Arginine in <i>C9ORF72</i> Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity.

Radwan, Mona; Ang, Ching-Seng; Ormsby, Angelique R; Cox, Dezerae; Daly, James C; Reid, Gavin E; Hatters, Danny M

Arginine in C9ORF72 Dipolypeptides Mediates Promiscuous Proteome Binding and Multiple Modes of Toxicity.

Radwan, Mona; Ang, Ching-Seng; Ormsby, Angelique R; Cox, Dezerae; Daly, James C; Reid, Gavin E; Hatters, Danny M.

Afiliação

Radwan M; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia; Bio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, Victoria, Australia.
Ang CS; Bio21 Mass Spectrometry and Proteomics Facility, The University of Melbourne, Parkville, Victoria, Australia.
Ormsby AR; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia.
Cox D; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia.
Daly JC; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia.
Reid GE; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia; School of Chemistry, The University of Melbourne, VIC 3010, Australia.
Hatters DM; Department of Biochemistry and Molecular Biology; and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia. Electronic address: dhatters@unimelb.edu.au.

Mol Cell Proteomics ; 19(4): 640-654, 2020 04.

Article em En | MEDLINE | ID: mdl-32086375

Assuntos

Arginina/metabolismo; Arginina/toxicidade; Proteína C9orf72/metabolismo; Peptídeos/metabolismo; Proteoma/metabolismo; Citoesqueleto de Actina/efeitos dos fármacos; Citoesqueleto de Actina/metabolismo; Animais; Proteínas de Fluorescência Verde/metabolismo; Células HEK293; Humanos; Metilação/efeitos dos fármacos; Camundongos; Modelos Biológicos; Ligação Proteica/efeitos dos fármacos; Biossíntese de Proteínas/efeitos dos fármacos; Ribossomos/metabolismo

Palavras-chave

Neurodegenerative diseases; RAN-translation; amyotrophic lateral sclerosis (ALS); methylation; methylosome; molecular biology; networks; protein aggregation; protein identification; protein-protein interactions; proteotoxicity; translation

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Arginina / Proteoma / Proteína C9orf72 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google