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Physical and biological properties of alginate/carbon nanofibers hydrogel films.
Llorens-Gámez, Mar; Salesa, Beatriz; Serrano-Aroca, Ángel.
Afiliação
  • Llorens-Gámez M; Escuela Técnica Superior de Arquitectura, Universitat Politècnica de València, Camí de Vera s/n, 46022 Valencia, Spain.
  • Salesa B; Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain.
  • Serrano-Aroca Á; Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain. Electronic address: angel.serrano@ucv.es.
Int J Biol Macromol ; 151: 499-507, 2020 May 15.
Article em En | MEDLINE | ID: mdl-32088232
ABSTRACT
Alginates are renewable materials with excellent biocompatibility and cost-effectiveness in comparison with other biodegradable polymers. However, these hydrogels have poor mechanical properties that restrict their applications in biomedical fields such as skin tissue engineering. In this regard, the study follows an enhanced engineering route to produce alginate-based films reinforced with different amounts (0, 0.1, 0.5, 1 and 2% w/w) of carbon nanofibers (CNFs) and characterize their physical and biological properties. The results of this study showed that these composites possess similar biological properties to neat alginate hydrogels. Thus, none of the synthesized composite materials were cytotoxic and no cell adhesion was observed on the films. Water sorption at the body temperature did not suffer strong changes with the incorporation of CNFs into the alginate matrix. The dynamic mechanical and tensile/compressive properties of calcium alginate significantly improved with the addition of even a very low amount of CNFs. Thus, the tensile and compression modulus of the calcium alginate films in the dry and hydrated state increases up to three and six times, respectively, with the addition of 2% w/w CNFs. In addition, the composites reinforced with the lowest CNFs content have the advantage of possessing more transparency and lower production costs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbono / Alginatos / Nanofibras / Metilgalactosídeos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbono / Alginatos / Nanofibras / Metilgalactosídeos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article