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Exploration of Rapid Evaporative-Ionization Mass Spectrometry as a Shotgun Approach for the Comprehensive Characterization of Kigelia Africana (Lam) Benth. Fruit.
Arena, Katia; Rigano, Francesca; Mangraviti, Domenica; Cacciola, Francesco; Occhiuto, Francesco; Dugo, Laura; Dugo, Paola; Mondello, Luigi.
Afiliação
  • Arena K; Foundation A. Imbesi c/o University of Messina, Messina, Italy.
  • Rigano F; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, I-98168 Messina, Italy.
  • Mangraviti D; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, I-98168 Messina, Italy.
  • Cacciola F; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, I-98168 Messina, Italy.
  • Occhiuto F; Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, I-98168 Messina, Italy.
  • Dugo L; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, I-98168 Messina, Italy.
  • Dugo P; Department of Sciences and Technologies for Human and Environment, University Campus Bio-Medico of Rome, I-00128 Rome, Italy.
  • Mondello L; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, I-98168 Messina, Italy.
Molecules ; 25(4)2020 Feb 20.
Article em En | MEDLINE | ID: mdl-32093421
Rapid evaporative-ionization mass spectrometry (REIMS) coupled with an electroknife as a sampling device was recently employed in many application fields to obtain a rapid characterization of different samples without any need for extraction or cleanup procedures. In the present research, REIMS was used to obtain a metabolic profiling of the Kigelia africana fruit, thus extending the applicability of such a technique to the investigation of phytochemical constituents. In particular, the advantages of REIMS linked to a typical electrosurgical handpiece were applied for a comprehensive screening of this botanical species, by exploiting the mass accuracy and tandem MS capabilities of a quadrupole-time of flight analyzer. Then, 78 biomolecules were positively identified, including phenols, fatty acids and phospholipids. In the last decade, Kigelia africana (Lam.) Benth. fruit has attracted special interest for its drug-like properties, e.g., its use for infertility treatments and as anti-tumor agent, as well as against fungal and bacterial infections, diabetes, and inflammatory processes. Many of these properties are currently correlated to the presence of phenolic compounds, also detected in the present study, while the native lipid composition is here reported for the first time and could open new directions in the evaluation of therapeutic activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Bignoniaceae / Frutas / Hipoglicemiantes / Anti-Inflamatórios / Antibacterianos / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Bignoniaceae / Frutas / Hipoglicemiantes / Anti-Inflamatórios / Antibacterianos / Antineoplásicos Fitogênicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article