Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis.

Zamanian-Daryoush, Maryam; Gogonea, Valentin; DiDonato, Anthony J; Buffa, Jennifer A; Choucair, Ibrahim; Levison, Bruce S; Hughes, Randall A; Ellington, Andrew D; Huang, Ying; Li, Xinmin S; DiDonato, Joseph A; Hazen, Stanley L

Zamanian-Daryoush, Maryam; Gogonea, Valentin; DiDonato, Anthony J; Buffa, Jennifer A; Choucair, Ibrahim; Levison, Bruce S; Hughes, Randall A; Ellington, Andrew D; Huang, Ying; Li, Xinmin S; DiDonato, Joseph A; Hazen, Stanley L.

Afiliação

Zamanian-Daryoush M; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Gogonea V; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, Ohio 44195.
DiDonato AJ; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Buffa JA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, Ohio 44195.
Choucair I; Department of Chemistry, Cleveland State University, Cleveland, Ohio 44115.
Levison BS; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Hughes RA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, Ohio 44195.
Ellington AD; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Huang Y; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, Ohio 44195.
Li XS; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
DiDonato JA; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, Ohio 44195.
Hazen SL; Department of Chemistry, Cleveland State University, Cleveland, Ohio 44115.

J Biol Chem ; 295(15): 4836-4848, 2020 04 10.

Article em En | MEDLINE | ID: mdl-32098873

Assuntos

5-Hidroxitriptofano/metabolismo; Transportador 1 de Cassete de Ligação de ATP/metabolismo; Apolipoproteína A-I/metabolismo; Arildialquilfosfatase/metabolismo; Colesterol/metabolismo; Lipoproteínas HDL/biossíntese; Tirosina/metabolismo; 5-Hidroxitriptofano/genética; Transportador 1 de Cassete de Ligação de ATP/genética; Animais; Apolipoproteína A-I/genética; Arildialquilfosfatase/genética; Transporte Biológico; Humanos; Camundongos; Camundongos Knockout; Oxirredução; Ligação Proteica

Palavras-chave

apolipoprotein; apolipoprotein A-I dysfunction; atherosclerosis; cardiovascular disease; cholesterol; coronary artery disease; genetic code expansion; high-density lipoprotein (HDL); non-canonical amino acids; orthogonal translation; posttranslational modification; recombinant protein expression; synthetic biology; tryptophan

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tirosina / 5-Hidroxitriptofano / Colesterol / Apolipoproteína A-I / Arildialquilfosfatase / Transportador 1 de Cassete de Ligação de ATP / Lipoproteínas HDL Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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