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Lipopolysaccharide induces filtrate leakage from renal tubular lumina into the interstitial space via a proximal tubular Toll-like receptor 4-dependent pathway and limits sensitivity to fluid therapy in mice.
Nakano, Daisuke; Kitada, Kento; Wan, Ningning; Zhang, Yahua; Wiig, Helge; Wararat, Kittikulsuth; Yanagita, Motoko; Lee, Syann; Jia, Lin; Titze, Jens M; Nishiyama, Akira.
Afiliação
  • Nakano D; Department of Pharmacology, Kagawa University, Kagawa, Japan. Electronic address: dnakano@med.kagawa-u.ac.jp.
  • Kitada K; Department of Pharmacology, Kagawa University, Kagawa, Japan; Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore.
  • Wan N; Department of Pharmacology, Kagawa University, Kagawa, Japan.
  • Zhang Y; Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Wiig H; Department of Biomedicine, University of Bergen, Bergen, Norway.
  • Wararat K; Department of Pharmacology, Kagawa University, Kagawa, Japan.
  • Yanagita M; Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Lee S; Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Jia L; Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  • Titze JM; Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore.
  • Nishiyama A; Department of Pharmacology, Kagawa University, Kagawa, Japan.
Kidney Int ; 97(5): 904-912, 2020 05.
Article em En | MEDLINE | ID: mdl-32107020
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Receptor 4 Toll-Like Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipopolissacarídeos / Receptor 4 Toll-Like Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article