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ISEcp1-Mediated Transposition Leads to Fosfomycin and Broad-Spectrum Cephalosporin Resistance in Klebsiella pneumoniae.
Kieffer, Nicolas; Poirel, Laurent; Mueller, Linda; Mancini, Stefano; Nordmann, Patrice.
Afiliação
  • Kieffer N; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
  • Poirel L; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland laurent.poirel@unifr.ch.
  • Mueller L; INSERM European Unit (IAME), University of Fribourg, Fribourg, Switzerland.
  • Mancini S; Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Fribourg, Switzerland.
  • Nordmann P; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Antimicrob Agents Chemother ; 64(5)2020 04 21.
Article em En | MEDLINE | ID: mdl-32122889
ABSTRACT
A fosfomycin-resistant and carbapenemase (OXA-48)-producing Klebsiella pneumoniae isolate was recovered, and whole-genome sequencing revealed ISEcp1-blaCTX-M-14b tandemly inserted upstream of the chromosomally encoded lysR-fosA locus. Quantitative evaluation of the expression of lysR and fosA genes showed that this insertion brought a strong hybrid promoter leading to overexpression of the fosA gene, resulting in fosfomycin resistance. This work showed the concomitant acquisition of resistance to broad-spectrum cephalosporins and fosfomycin due to a single genetic event.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cefalosporinas / Farmacorresistência Bacteriana Múltipla / Fosfomicina / Klebsiella pneumoniae / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cefalosporinas / Farmacorresistência Bacteriana Múltipla / Fosfomicina / Klebsiella pneumoniae / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article