Synthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer.

Leong, Sze Wei; Chia, Suet Lin; Abas, Faridah; Yusoff, Khatijah

Leong, Sze Wei; Chia, Suet Lin; Abas, Faridah; Yusoff, Khatijah.

Afiliação

Leong SW; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia. Electronic address: frederick_leong@hotmail.com.
Chia SL; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia. Electronic address: suetlin@upm.edu.my.
Abas F; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia; Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
Yusoff K; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia; Malaysia Genome Institute (MGI), National Institute of Biotechnology Malaysia (NIBM), Jalan Bangi, 43000 Kajang, Selangor Darul Ehsan, Malaysi

Bioorg Med Chem Lett ; 30(8): 127065, 2020 04 15.

Article em En | MEDLINE | ID: mdl-32127259

Assuntos

Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Neoplasias Colorretais/tratamento farmacológico; Ácidos Pentanoicos/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Neoplasias Colorretais/patologia; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Estrutura Molecular; Ácidos Pentanoicos/síntese química; Ácidos Pentanoicos/química; Relação Estrutura-Atividade

Palavras-chave

Apoptosis; Cell cycle; Colorectal cancer; Cytotoxicity; Diarylpentanoids

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácidos Pentanoicos / Neoplasias Colorretais / Apoptose / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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