A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine-Ketamine Combination Sedation for Transthoracic Echocardiography in Pediatric Patients With Congenital Heart Disease: A Randomized Controlled Trial.
J Cardiothorac Vasc Anesth
; 34(6): 1550-1555, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32127283
ABSTRACT
OBJECTIVES:
To compare the effects of intranasal dexmedetomidine (DEX) and DEX-ketamine (KET) on hemodynamics and sedation quality in children with congenital heart disease.DESIGN:
A randomized controlled, double-blind, prospective trial.SETTING:
A tertiary care teaching hospital.PARTICIPANTS:
The study comprised 60 children undergoing transthoracic echocardiography (TTE).INTERVENTIONS:
Patients were randomly allocated into the DEX group (group D [nâ¯=â¯30]) or the DEX-KET group (group D-K [nâ¯=â¯30]). Group D received 2 µg/kg of intranasal DEX; group D-K received 2 µg/kg of DEX and 1 mg/kg of KET intranasally. MEASUREMENTS AND MAINRESULTS:
The primary outcome was the change in hemodynamics, measured using mean arterial pressure (MAP) and heart rate (HR). Secondary outcomes were onset time, wake-up time, and discharge time. No differences were found in mean arterial pressure or heart rate. The onset time was significantly shorter in group D-K than in group D (9.6 ± 2.9 minutes v 14.3 ± 3.4 minutes; pâ¯=â¯0.031). The wake-up time was longer in group D-K than in group D (52 ± 14.7 minutes v 39.6 ± 12.1 minutes; pâ¯=â¯0.017). The discharge time was longer in group D-K than in group D (61.33 ± 11.59 minutes v 48.17 ± 8.86 minutes; p < 0.001). No differences in hemodynamics were found between the 2 groups. Intranasal DEX was found to be as effective for TTE sedation as intranasal DEX-KET, with longer onset time and shorter recovery and discharge times.CONCLUSION:
No differences in hemodynamics were found between the 2 groups. Intranasal DEX was found to be as effective for TTE sedation as is intranasal DEX-KET, with longer onset time and shorter recovery and discharge times.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dexmedetomidina
/
Cardiopatias Congênitas
/
Ketamina
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article